Endocrine Abstracts

Hypothalamic inflammation has been the focus of an increasing number of studies in recent years as it is thought to underlie the pathogenesis of obesity-associated insulin resistance and type 2 diabetes. These studies have also highlighted the role of glial cells in metabolic control, due to the fact that both microglia and astrocytes are involved in central inflammatory processes. High fat diet (HFD)-induced obesity has been the most commonly used model for the analysis of th...

Our health and wellbeing are influenced by numerous factors, including our early developmental hormonal and nutritional environments. Indeed, modifications of hormones and nutrition during specific developmental periods can have long-lasting effects on fundamental functions such as metabolism and reproduction, with these long-term changes often being sex dependent. Moreover, modifications in one neuroendocrine system can have an important impact on other neuroendocrine axes, a...

Background: Brown adipose tissue (BAT) plays a pivotal role in the regulation of energy homeostasis and thermogenesis. This tissue responds to insulin, favoring the expression of uncoupling protein-1 (UCP-1), that in turn is inhibited by insulin-desensitizing cytokines. Leptin may abolish some of the effects of fasting on these parameters through its cross-talk with insulin-related signaling targets.Objectives: We hypothesized that leptin infusion preven...